Blood oxygenation level–dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease
Identifieur interne : 001E30 ( Main/Exploration ); précédent : 001E29; suivant : 001E31Blood oxygenation level–dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease
Auteurs : Janey Prodoehl [États-Unis] ; Mathew Spraker [États-Unis] ; Daniel Corcos [États-Unis] ; Cynthia Comella [États-Unis] ; David Vaillancourt [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, BOLD, Basal Ganglia (blood supply), Basal ganglion, Brain Mapping, Case-Control Studies, De novo, Female, Hand Strength (physiology), Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Nervous system diseases, Nuclear magnetic resonance imaging, Oxygen (blood), Oxygenation, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Prospective Studies, Regression Analysis, Severity of Illness Index, Thalamus (blood supply), basal ganglia, disease severity, fMRI.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Basal Ganglia, Thalamus.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Hand Strength.
- physiopathology : Parkinson Disease.
- Adult, Aged, Brain Mapping, Case-Control Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Regression Analysis, Severity of Illness Index.
Abstract
To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity. This study examines the relation between blood oxygenation level–dependent (BOLD) activation in every nucleus of the BG and symptom‐specific disease severity in early stage de novo PD. BOLD activation measured at 3 T was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the BG nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified PD Rating Scale and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the BG and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the BG relates most consistently to bradykinesia and functional magnetic resonance imaging has strong potential to serve as a noninvasive marker for the state of BG function in de novo PD. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/9B4C23B0A7FA67EC95349FD0105EF07BB87517D2/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952037
DOI: 10.1002/mds.23360
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000435
- to stream Istex, to step Curation: 000435
- to stream Istex, to step Checkpoint: 000B09
- to stream Pmc, to step Corpus: 000111
- to stream Pmc, to step Curation: 000111
- to stream Pmc, to step Checkpoint: 000364
- to stream PubMed, to step Corpus: 001613
- to stream PubMed, to step Curation: 001613
- to stream PubMed, to step Checkpoint: 001A20
- to stream Ncbi, to step Merge: 002E04
- to stream Ncbi, to step Curation: 002E04
- to stream Ncbi, to step Checkpoint: 002E04
- to stream Main, to step Merge: 002266
- to stream PascalFrancis, to step Corpus: 000880
- to stream PascalFrancis, to step Curation: 002439
- to stream PascalFrancis, to step Checkpoint: 000B85
- to stream Main, to step Merge: 002772
- to stream Main, to step Curation: 001E30
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Blood oxygenation level–dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease</title><author><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name></author><author><name sortKey="Spraker, Mathew" sort="Spraker, Mathew" uniqKey="Spraker M" first="Mathew" last="Spraker">Mathew Spraker</name></author><author><name sortKey="Corcos, Daniel" sort="Corcos, Daniel" uniqKey="Corcos D" first="Daniel" last="Corcos">Daniel Corcos</name></author><author><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name></author><author><name sortKey="Vaillancourt, David" sort="Vaillancourt, David" uniqKey="Vaillancourt D" first="David" last="Vaillancourt">David Vaillancourt</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9B4C23B0A7FA67EC95349FD0105EF07BB87517D2</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23360</idno><idno type="url">https://api.istex.fr/document/9B4C23B0A7FA67EC95349FD0105EF07BB87517D2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000435</idno><idno type="wicri:Area/Istex/Curation">000435</idno><idno type="wicri:Area/Istex/Checkpoint">000B09</idno><idno type="wicri:doubleKey">0885-3185:2010:Prodoehl J:blood:oxygenation:level</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952037</idno><idno type="RBID">PMC:2952037</idno><idno type="wicri:Area/Pmc/Corpus">000111</idno><idno type="wicri:Area/Pmc/Curation">000111</idno><idno type="wicri:Area/Pmc/Checkpoint">000364</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001613</idno><idno type="wicri:Area/PubMed/Curation">001613</idno><idno type="wicri:Area/PubMed/Checkpoint">001A20</idno><idno type="wicri:Area/Ncbi/Merge">002E04</idno><idno type="wicri:Area/Ncbi/Curation">002E04</idno><idno type="wicri:Area/Ncbi/Checkpoint">002E04</idno><idno type="wicri:doubleKey">0885-3185:2010:Prodoehl J:blood:oxygenation:level</idno><idno type="wicri:Area/Main/Merge">002266</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:10-0474348</idno><idno type="wicri:Area/PascalFrancis/Corpus">000880</idno><idno type="wicri:Area/PascalFrancis/Curation">002439</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B85</idno><idno type="wicri:doubleKey">0885-3185:2010:Prodoehl J:blood:oxygenation:level</idno><idno type="wicri:Area/Main/Merge">002772</idno><idno type="wicri:Area/Main/Curation">001E30</idno><idno type="wicri:Area/Main/Exploration">001E30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Blood oxygenation level–dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease</title><author><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Spraker, Mathew" sort="Spraker, Mathew" uniqKey="Spraker M" first="Mathew" last="Spraker">Mathew Spraker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Corcos, Daniel" sort="Corcos, Daniel" uniqKey="Corcos D" first="Daniel" last="Corcos">Daniel Corcos</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Vaillancourt, David" sort="Vaillancourt, David" uniqKey="Vaillancourt D" first="David" last="Vaillancourt">David Vaillancourt</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-15">2010-10-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="2035">2035</biblScope><biblScope unit="page" to="2043">2043</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9B4C23B0A7FA67EC95349FD0105EF07BB87517D2</idno><idno type="DOI">10.1002/mds.23360</idno><idno type="ArticleID">MDS23360</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>BOLD</term><term>Basal Ganglia (blood supply)</term><term>Basal ganglion</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>De novo</term><term>Female</term><term>Hand Strength (physiology)</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Oxygen (blood)</term><term>Oxygenation</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prospective Studies</term><term>Regression Analysis</term><term>Severity of Illness Index</term><term>Thalamus (blood supply)</term><term>basal ganglia</term><term>disease severity</term><term>fMRI</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Basal Ganglia</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>De novo</term><term>Imagerie RMN</term><term>Maladie de Parkinson</term><term>Noyau gris central</term><term>Oxygénation</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity. This study examines the relation between blood oxygenation level–dependent (BOLD) activation in every nucleus of the BG and symptom‐specific disease severity in early stage de novo PD. BOLD activation measured at 3 T was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the BG nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified PD Rating Scale and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the BG and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the BG relates most consistently to bradykinesia and functional magnetic resonance imaging has strong potential to serve as a noninvasive marker for the state of BG function in de novo PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name></region><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name><name sortKey="Corcos, Daniel" sort="Corcos, Daniel" uniqKey="Corcos D" first="Daniel" last="Corcos">Daniel Corcos</name><name sortKey="Corcos, Daniel" sort="Corcos, Daniel" uniqKey="Corcos D" first="Daniel" last="Corcos">Daniel Corcos</name><name sortKey="Corcos, Daniel" sort="Corcos, Daniel" uniqKey="Corcos D" first="Daniel" last="Corcos">Daniel Corcos</name><name sortKey="Corcos, Daniel" sort="Corcos, Daniel" uniqKey="Corcos D" first="Daniel" last="Corcos">Daniel Corcos</name><name sortKey="Spraker, Mathew" sort="Spraker, Mathew" uniqKey="Spraker M" first="Mathew" last="Spraker">Mathew Spraker</name><name sortKey="Vaillancourt, David" sort="Vaillancourt, David" uniqKey="Vaillancourt D" first="David" last="Vaillancourt">David Vaillancourt</name><name sortKey="Vaillancourt, David" sort="Vaillancourt, David" uniqKey="Vaillancourt D" first="David" last="Vaillancourt">David Vaillancourt</name><name sortKey="Vaillancourt, David" sort="Vaillancourt, David" uniqKey="Vaillancourt D" first="David" last="Vaillancourt">David Vaillancourt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E30 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E30 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9B4C23B0A7FA67EC95349FD0105EF07BB87517D2
|texte= Blood oxygenation level–dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |